JayCel™-SMCC 50 LD

JayCel™-SMCC 50 LD is a low-density Silicified Microcrystalline Cellulose engineered for optimized flow behavior, enhanced compressibility, and superior formulation uniformity in direct compression applications. Combining the functional advantages of Microcrystalline Cellulose with colloidal silicon dioxide, it delivers reliable processing efficiency, improved tablet integrity, reduced segregation, and stable manufacturing performance across pharmaceutical and nutraceutical solid dosage formulations.

Technical Details

JayCel™-SMCC 50 LD Silicified Microcrystalline Cellulose

Appearance Free-Flowing Powder

pH Range 5.0 – 7.5

Assay Dried 97.0 – 102.0%

Bulk Density 0.26 – 0.34 g/ml

Physical Characteristics

Description White or almost white, very fine to moderately fine powder. It is a free-flowing material. Reference: USP

Solubility in Sodium Hydroxide Slightly soluble in sodium hydroxide solution. Reference: Ph. Eur / BP

General Solubility Practically insoluble in water, acetone, ethanol, toluene, and dilute acid. Reference: Ph. Eur / BP

Solubility in Ammonical Copper Tetramine It dissolves completely, leaving no residue. Reference: IP / BP / Ph. Eur. / USP-NF

pH pH of the supernatant solution should between 5.0 to 7.5. Reference: USP/NF, JP, Ph.Eur., BP

Conductivity Conductivity of the supernatant solution should not exceed 75 µS per cm. Reference: USP/NF, JP, Ph.Eur., BP

Loss on Drying Not More than 5.0% w/w. Reference: USP/NF, JP, Ph.Eur., BP

Bulk Density 0.26 to 0.34 g/ml. Reference: In house

Degree of Brightness ≥ 85 % Reference: In house

Angle of Repose 38 - 48° Reference: In house

Identification & Compliance

Infrared Absorption Violet-blue colour should be produced. Reference: JP / USP

Color Reaction Deep yellow color is produced. Reference: USP / Ph.Eur / BP / JP

Variance Variance should not exceed 0.02. Reference: USP / Ph.Eur / BP / JP

Chemical Purity Profile

Residue on Ignition / Sulphated Ash 1.8 - 2.2 % W / W Reference: USP/NF, JP, Ph.Eur., BP

Starch & Dextrins Complies with IP limit test. Reference: IP

Organic Impurities Have to correspond as per IP. Reference: IP

Water Soluble Substances Not More than 0.25% w/w. Reference: USP/NF, JP, Ph.Eur., BP

Ether Soluble Substances Not More than 0.05% w/w. Reference: USP/NF, JP, Ph.Eur., BP

Heavy Metals Not More than 10 ppm. Reference: USP/NF, JP, Ph.Eur., BP

Arsenic Not More than 2 PPM Reference: IP

Assay (Dried) 97.0 – 102.0 Reference: IP

Particle Size Distribution

D10

14 – 30 µ

Reference: In house

D50

40 – 75 µ

Reference: In house

D90

77 – 156 µ

Reference: In house

Sieve Analysis

60 Mesh Retention ≤ 1.0% Reference: In house

200 Mesh Retention ≤ 30.0% Reference: In house

Microbial Safety Standards

Total aerobic microbial count
1000 cfu/g Reference: USP/NF, JP, Ph.Eur., BP

Total combined molds & yeasts
100 cfu/g Reference: USP/NF, JP, Ph.Eur., BP

Staphylococcus aureus
Absent Reference: USP/NF, JP, Ph.Eur., BP

Pseudomonas aeruginosa
Absent Reference: USP/NF, JP, Ph.Eur., BP

Escherichia coli
Absent Reference: USP/NF, JP, Ph.Eur., BP

Salmonella species
Absent Reference: USP/NF, JP, Ph.Eur., BP

Storage & Solvent Compliance

Organic Volatile Impurities Product does not contain solvents listed in Organic Volatile Impurities. Reference: USP <467>

Residual Solvents Product does not contain residual solvents. Reference: Ph.Eur <5.4>

Storage Recommendation Preserve in tight containers. Reference: Specification Requirement

Technical Note: JayCel™-SMCC 50 LD specifications are designed to support low-density formulation handling, enhanced compressibility, and reliable compliance across pharmaceutical and nutraceutical direct-compression applications.