JayCel™-112

JayCel™-112 is a low-moisture pharmaceutical-grade Microcrystalline Cellulose engineered for superior flow characteristics, enhanced processing efficiency, and stable formulation performance. Designed with controlled particle distribution and reduced moisture content, it provides excellent compressibility, reliable blending behavior, and consistent tablet manufacturing performance across pharmaceutical, nutraceutical, and high-speed production applications.

Technical Details

JayCel™-112 Microcrystalline Cellulose

AppearanceWhite Powder

pH Range5.0 – 7.5

Assay Dried97.0 – 102.0%

Bulk Density0.27 – 0.36 g/ml

Physical Characteristics

DescriptionWhite or almost white, fine or granular crystalline powder.Reference: USP

SolubilityInsoluble in water, dilute acids, and most organic solvents including anhydrous ethanol, acetone, and toluene.Reference: Ph. Eur / BP

Sodium Hydroxide SolubilityPractically insoluble in sodium hydroxide solution.Reference: Ph. Eur / BP

Special Solubility TestDissolve 50 mg in 10 ml ammonical solution of copper tetramine R. It dissolves completely, leaving no residue.Reference: Ph. Eur / BP

pHpH of the supernatant solution should be between 5.0 to 7.5.Reference: USP/NF, JP, Ph.Eur, BP

ConductivityConductivity of the supernatant solution should not exceed 75 µS/cm.Reference: USP/NF, JP, Ph.Eur, BP

Loss on DryingNot more than 1.5% w/w.Reference: USP/NF, JP, Ph.Eur, BP

Bulk Density0.27 to 0.36 g/ml.Reference: In-house

Degree of Brightness85%.Reference: In-house

Angle of ReposeMaximum 42°.Reference: In-house

Identification & Compliance

Infrared AbsorptionRecord the infrared absorption spectrum and compare with the reference spectrum.Reference: JP / USP

Color ReactionThe substance takes on a violet-blue color.Reference: USP, Ph.Eur, BP, JP

Degree of PolymerizationNot more than 350.Reference: USP, Ph.Eur, BP, JP

Chemical Purity Profile

Residue on Ignition / Sulphated AshNot more than 0.1%.Reference: USP/NF, JP, Ph.Eur, BP

Starch & DextrinsComplies with IP limit test.Reference: IP

Organic ImpuritiesHave to correspond as per IP.Reference: IP

Water Soluble SubstancesNot more than 0.25% w/w.Reference: USP/NF, JP, Ph.Eur, BP

Ether Soluble SubstancesNot more than 0.05% w/w.Reference: USP/NF, JP, Ph.Eur, BP

Heavy MetalsNot more than 10 ppm.Reference: USP/NF, JP, Ph.Eur, BP

ArsenicNot more than 2 ppm.Reference: IP

Assay Dried97.0 – 102.0%.Reference: In-house

Particle Size Distribution

D10

≤ 45 µ

Reference: In-house

D50

70 – 100 µ

Reference: In-house

D90

≥ 140 µ

Reference: In-house

Sieve Analysis

60 Mesh Retention≤ 8.0%.Reference: In-house

200 Mesh Retention≤ 45.0%.Reference: In-house

Microbial Safety Standards

Total Aerobic Microbial Count
Maximum 1000 cfu/g.Reference: USP/NF, JP, Ph.Eur, BP

Total Combined Molds & Yeasts
Maximum 100 cfu/g.Reference: USP/NF, JP, Ph.Eur, BP

Staphylococcus aureus
Absent.Reference: USP/NF, JP, Ph.Eur, BP

Pseudomonas aeruginosa
Absent.Reference: USP/NF, JP, Ph.Eur, BP

Escherichia coli
Absent.Reference: USP/NF, JP, Ph.Eur, BP

Salmonella species
Absent.Reference: USP/NF, JP, Ph.Eur, BP

Storage & Solvent Compliance

Storage RecommendationPreserve in tight containers.Reference: Specification Requirement

Organic Volatile ImpuritiesRaw materials, manufacturing process, and product do not contain solvents listed in Organic Volatile Impurities.Reference: USP <467>

Residual SolventsRaw materials, manufacturing process, and product do not contain listed residual solvents.Reference: Ph.Eur <5.4>

Technical Note: JayCel™-112 specifications are designed to support low-moisture stability, controlled flowability, and reliable compliance across pharmaceutical and industrial formulation requirements.